The simcyp division of certara uk limited was founded as simcyp limited in 2001 by professors geoff tucker and amin rostami hodjegan as a spinout company from the university of sheffield, uk. The simcyp populationbased adme simulator citation. Amin rostamihodjegans research works the university of. Amin rostami joz eshghe to ft peyman amin amin rostami mano too ghalbet negah dar. Aug 20, 20 certara is developing a systems and populationbased approach to help with early preclinical assessment of drug toxicity risk, said dr. Zoe barters research works wwf united kingdom, london. Delineating the role of various factors in renal disposition. Development of submodels of organs within physiologicallybased pharmacokinetic pbpk principles and beyond simple perfusion limitations may be challenging because of underdeveloped in vitroin vivo extrapolation approaches or lack of suitable clinical data for model refinement. A library of drug trial simulation models and examples. Certara is contributing to 28 sessions, showcasing modeling by its pharmacometricians, systems pharmacologists, and experts in pharmacoeconomicshealth economics outcomes research. More than 90% of novel new drug approvals by the us food and drug administration fda are supported by certara software or services. Professor rostami has an active program of training phd students involving proteomics, pbpk, clinical pkpd and precision dosing.
Listen and download baroon by amin rostami for free now on irantune, browse new musicsmp3s and videos on irantune. This research was supported by the us food and drug administrations fdas medical countermeasures initiative. He is an original thinker, who can envision how to combine disciplines to disrupt the status quo and improve the drug development paradigm, said certara chief executive. Prof amin rostamihodjegan pharmd, phd, fcp, faaps, fjssx. Certara signs research agreement with the hamner institutes. Towards further verification of physiologicallybased kidney. Considering age variation when coining drugs as high versus.
The simcyp populationbased adme simulator request pdf. Rose, gaohua lu, theresa cain, khaled abduljalil, nikunjkumar patel and masoud jamei are employees of simcyp limited a certara company. Amin rostami hodjegan and geoff tucker have a longstanding track record in exploring the scientific background of metabolic drugdrug interactions. He joined certara in 2012 as a cofounder of simcyp limited a university of sheffield spinoff which was acquired by certara.
Academic unit of clinical pharmacology, floor m, the royal hallamshire hospital, sheffield s10 2jf, and simcyp ltd, the blades enterprise centre, john street, sheffield, s2 4su, uk amin rostami. Prediction success criteria for pharmacokinetic parameters. Professor rostami has an active program of training phd students involving. Limited in 2001 by professors geoff tucker and amin rostamihodjegan as a. Certara corporation promotes professor amin rostami to senior. Our mission is to understand what happens to drugs when they enter the body where they go, how they are metabolised and how quickly.
In silico modeling of gastrointestinal drug absorption. This work was funded by simcyp limited a certara company. Certara is dedicated to improving human health through a broad spectrum of software. In vitroin vivo extrapolation ivive of renal excretory clearance clr using the physiologically based kidney models can provide mechanistic insight into the interplay of multiple processes occurring in the renal tubule. Simulation and prediction of in vivo drug metabolism in.
Certara scientists to highlight modelinformed drug development, pbpk, mbma and quantitative systems pharmacology progress at page 2019 posted jun 10, 2019. Simcyp releases version of its widely used simulator. Simcyp is based in sheffield, uk simcyps simulators allow in silico prediction of drug absorption, distribution, metabolism and excretion and potential drugdrug interactions. Certara scientists to present their latest modeling and. Masoud jamei, steve marciniak, duncan edwards, kris wrag, kairui feng and adrian barnett are employees in simcyp limited a certara company. In addition to its use in clinical and regulatory approval, the simcyp simulator is actively being leveraged for formulations and pharmaceutics development purposes, said amin rostami, pharmd, phd, certaras chief scientific officer. The companys flagship product the simcyp populationbased adme simulator is used by the worlds top pharmaceutical companies and is recognised as the industrys most sophisticated platform for the simulation of. Mechanistic pbpk modeling and simulation has become a key technology in modern drug development. Simcyp was acquired by certara in 2012 with its name changing to certara uk simcyp division in 2018 and has continued experience dynamic growth.
Oct 16, 2019 in addition to its use in clinical and regulatory approval, the simcyp simulator is actively being leveraged for formulations and pharmaceutics development purposes, said amin rostami, pharmd. Commenting on the new release, professor amin rostami, vice president of research and development at simcyp, said. Certara scientists to highlight modelinformed drug. Nov 26, 2014 amin rostami hodjegan is an employee of the university of manchester and parttime secondee to simcyp limited a certara company. Amin rostami hodjegan is an employee of the university of manchester and parttime secondee to simcyp limited a certara company. Simulation and prediction of in vivo drug metabolism. Nov 04, 2019 this is such an exciting time to be working in modelinformed drug development, said certara chief scientific officer professor amin rostami. It is also an excellent addition to the many scientific and regulatory accomplishments that the simcyp team has achieved during the past 20 years, said certara chief scientific officer professor amin rostami. Certara celebrates 20th anniversary of the simcyp simulator consortium. Certara celebrates 20th anniversary of the simcyp simulator. Previous workshops school of pharmacy and pharmaceutical. Kris wragg bsc software engineering simcyp, sheffield. Certara is dedicated to improving human health through a broad spectrum of software products and.
Considering age variation when coining drugs as high. In addition to its use in clinical and regulatory approval, the simcyp simulator is actively being leveraged for formulations and pharmaceutics development purposes, said amin rostami, pharmd. Certaras trial simulator is a suite of tools for simulating clinical drug trials. Considering age variation when coining drugs as high versus low hepatic extraction ratios farzaneh salem, khaled abduljalil, yoshiteru kamiyama, and amin rostami hodjegan simcyp limited a certara company, sheffield, united kingdom f. Simcyp s research is funded by a consortium of pharma companies.
As a cofounder of simcyp limited a university of sheffield spinoff acquired by certara he is parttime secondee at certara. Virtual bioequivalence represents an ideal application for simcyp s pbpk modeling and simulation capabilities. All simulations presented herein were performed using the simcyp populationbased pbpk simulator software, version 14, release 1 simcyp, sheffield, uk jamei et al. Shifting from clinical studies to predict and confirm, day 2 amin rostamihodjegan moderator 9. Zoe barters research works wwf united kingdom, london and. The simcyp populationbased absorption, distribution, metabolism and excretion simulator is a platform and database for bottomup mechanistic modelling and simulation of the processes of oral absorption, tissue distribution, metabolism and excretion of drugs and drug candidates in healthy and disease populations. As a cofounder of simcyp limited a university of sheffield spinoff acquired by.
Academic unit of clinical pharmacology, floor m, the royal hallamshire hospital, sheffield s10 2jf, and simcyp ltd, the blades enterprise. The simcyp simulator the simcyp populationbased simulator software. The simcyp software platform 26, 27 has been widely used for pbpk modeling and simulation of pharmaceutical compounds by multiple commercial and academic groups. Aug 28, 20 commenting on the new release, professor amin rostami, vice president of research and development at simcyp, said. Towards quantitation of the effects of renal impairment. Amin rostami delam gereft ft fereydoon amin rostami bi marefat.
The centre for applied pharmacokinetic research capkr is a consortium of academic researchers at the university of manchester and nine industrial pharmaceutical companies. Professor amin rostami lecture tickets, mon 18112019 at. Our people a global workforce certaras solutions, which span the discovery, preclinical, and clinical stages of drug development, enable datadriven decisions, leading to more precisely designed trials with a reduced risk of failure and improved subject safety. Liver cirrhosis is characterized by a decrease in functional hepatocytes, lowered circulating levels of plasma proteins and alterations in blood flow due to the development of portacaval shunts. In addition to its use in clinical and regulatory approval, the simcyp simulator is actively being leveraged for formulations and pharmaceutics development purposes, said amin. The modeling was performed using simcyp software v18 certara ltd, sheffield, uk.
Certara scientists to give 22 presentations at the aaps. Architecture, implementation, and quality assurance masoud jamei1, steve marciniak1, duncan edwards1, kris wragg1, kairui feng1, adrian barnett1 and amin rostamihodjegan1,2 abstract developing a userfriendly platform that can handle a vast number of complex physiologically based. Frontiers applications of linking pbpk and pd models to. It determines the main physiological and biological elements of the system patient attributes that are most significant in interindividual variability of clearance. Original research open access the simcyp population. His mission is to ensure that the latest scientific advances in the field of biosimulation are incorporated into all of the drug development efforts by various pharmaceutical companies.
Prediction of drug kinetics in humans from in vitro data, apr 56, amin rostamihodjegan, phd, simcyp limited, sheffield, uk. Our simcyp simulator can already model the population variability in pharmacokinetic and pharmacodynamic responses and cardiotoxicity scenarios. View the profiles of professionals named amin rostami on linkedin. The hepatic extraction ratio eh is commonly considered an inherent attribute of drug. Many graduates from his team hold positions in the pharmaceutical industry or academia. Sep 30, 2012 prediction of the exposure of neonates, infants and children to xenobiotics is likely to be more successful using physiologically based pharmacokinetic models than simplistic allometric scaling, particularly in younger children. However, such models require comprehensive information on the ontogeny of anatomical, physiological and biochemical variables. In addition to its use in clinical and regulatory approval, the simcyp simulator is actively being leveraged for formulations and pharmaceutics development purposes, said. Physiologically based in silico absorption models have emerged as a widely used and promising supplement to traditional in vitro assays and preclinical in vivo studies. Oct 16, 2019 our organization continues to grow and evolve to tackle new frontiers. Initial simulations of digoxin plasma concentrationtime profiles and cl r were performed using the default healthy volunteers population file provided. Hodjegan holds shares in certara, a company focusing on model. Amin rostami 6 album demo kian zibandeh ta paie bi.
Rostami leads a team of scientists working on extrapolation of in vitro data on drug metabolism to predict in vivo pharmacokinetics and pharmacodynamics in virtual patient populations. Development of a novel simplified pbpk absorption model to. Amin rostamihodjegan and geoff tucker have a longstanding track record in exploring the scientific background of metabolic drugdrug interactions. Zoe barters research while affiliated with wwf united kingdom and other places. Professor amin rostami lecture tickets, mon 18112019 at 11. Amin rostami 6 album demo kian zibandeh ta paie bi kasi. Simcyps simulators allow in silico prediction of drug absorption, distribution, metabolism and excretion adme and potential drugdrug interactions. Physiologically based pharmacokinetic software packages gisim, simcyp. Amin rostami joz eshghe to ft peyman amin amin rostami tik tik.
Sep 02, 20 simcyp releases version of its widely used simulator. Certara is developing a systems and populationbased approach to help with early preclinical assessment of drug toxicity risk, said dr. Professor amin rostami, vp research and development, simcyp, said. This is such an exciting time to be working in modelinformed drug development, said certara chief scientific officer professor amin rostami. His mission is to ensure that the latest scientific advances in the field of biosimulation are incorporated into all of the drug development efforts by. Amin rostamihodjegan is an employee of the university of manchester and parttime secondee to simcyp limited a certara company. Depending on the interplay between these parameters and the characteristics of an administered drug, varying degrees of impaired systemic clearance and firstpass. Our organization continues to grow and evolve to tackle new frontiers. Prediction of the clearance of eleven drugs and associated.
Modeling and data analysis in pharmacokinetics and pharmacodynamics using adapt 5, apr 89, david d. Amin represents the epitome of scientific leadership. Request pdf the simcyp populationbased adme simulator the simcyp. Certara, the global biosimulation technologyenabled drug development and drug safety consulting company, today announced that it has promoted amin rostami, pharm. Structured literature searches were carried out using medline for the parameters cl and v ss of 17 compounds strictly after intravenous doses. The authors gratefully acknowledge professor amin rostamihodjegan from the university of manchester, manchester, uk and drs sibylle neuhoff and masoud jamei from simcyp ltd, sheffield, uk for their scientific input. Jun 03, 20 masoud jamei, steve marciniak, duncan edwards, kris wrag, kairui feng and adrian barnett are employees in simcyp limited a certara company. Certara corporation promotes professor amin rostami to. M jamei, s marciniak, k feng, a barnett, g tucker, a rostamihodjegan.
However, there remains a lack of comparative studies between different models. Gastrointestinal gi drug absorption is a complex process determined by formulation, physicochemical and biopharmaceutical factors, and gi physiology. A semimechanistic model to predict the effects of liver. Amin rostamihodjegans 402 research works with 139 citations and 6418. Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic pbpk modelling software article in seizure 33. Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be more successful using physiologically based pharmacokinetic models than simplistic allometric scaling, particularly in younger children. Trevor johnson is a paid employee of simcyp limited a certara company. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
Their efforts have culminated in the development of the mddi prediction software simcyp. Certara revenue, number of employees, annual growth and. Simcyp provides platforms for modelling and simulation of drug absorption, distribution, metabolism and excretion adme in virtual human populations and virtual laboratory animals. Publicprivate partnerships influencing drug development and regulatory decisionseuropean experiences with various models. Simcyp limited is a researchbased company which provides modelling and simulation software to the pharmaceutical industry for use during drug development. Certara revenue, number of employees, annual growth and funding. Original research open access the simcyp population based. However, advantage of such models in predicting clinical observations in divergent patient groups is now commonly. Simcyps research is funded by a consortium of pharma companies. Amin rostami delam gereft ft fereydoon amin rostami 6 album demo amin rostami khodahafez.
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